A new CANdiLab report published in PLoS ONE today utilized functional magnetic resonance imaging to demonstrate that healthy individuals are capable of modulating their own brain’s response to negative feedback. In the study, participants performed a time-estimation task during which they received positive or negative feedback to indicate how accurate they were at estimating a one-second duration. Participants first performed the task normally, and baseline neural responses were measured. Then participants were asked to perform the task again, but this time they were asked to “try to maximize your brain’s response every time you receive negative feedback”. Results indicated that participants were capable of this type of voluntary neuromodulation: they showed significantly increased activity on NegFeedbackINCREASE trials compared to NegFeedbackBASELINE trials within several regions known to underlie the processing of negative feedback, including the anterior cingulate and medial frontal cortex. Moreover, participants showed increased behavioral adjustments following negative feedback trials characterized by increased anterior cingulate response. These results suggest that healthy individuals may indeed be capable of modulating their own neural responses to negative feedback. CANdiLab plans to continue research in this area, to investigate the extent to which trained modulation may have implications for psychological disorders characterized by a hypervigilance to such stimuli (ie.internalizing disorders), and for facilitated learning platforms.